I guess so. It would be interesting to have a vampire story from the perspective of a perpetually young vampire, in both mind and body, who constantly wants new experiences. There's a dynasty in Vampire: the Masquerade like this, who see themselves as connoisseurs of life, art and experience. Their lives, which are comprised of wandering through successive epochs and cultures, are a bit like a wine taster's, working his or her way along a table of vintages.
I do think there's an appeal to this idea of things being lost, though. It's not just that a vampire will be overwhelmed by the appearance of electric lights, petrol engines and the internet - it's also that they'll remember the horse-drawn carriages of their youth, or the silver-topped cane that their sire poked them with to wake them up after their metamorphosis, and wish those things still existed within the same world-structure.