Old Games with Real People

[FataliOmega]

The Tex Murphy series used FMV. Worked great, as far as I'm concerned! :-)

Also Lands of Lore: Guardians of Destiny used it (though it was pretty silly looking at times.)

[k3n]

i still have my copy of the 7th guest special edition with the making of VHS tape. me thinks the tape has a really good interview with graeme devine on his days porting pole position for atari. if i only had a vcr...

The Making Of The 7th Guest (Part 1)
http://www.youtube.com/watch?v=HcuQoQrMjWM
seek to 2:25

The Making Of The 7th Guest (Part 2)
http://www.youtube.com/watch?v=fl6cSlOlxB8

[MangoMercury]

Don't forget Toonstruck!  While it's not an entire FMV, it is a cartoon adventure game featuring real people!

[Tage7]

The first game that came to my mind was Goosebumps: Escape from Horrorland. Then I stumbled upon a link on that page.