Hi, Wayne from QA here.
We've found this is a result of leaving the game right after Caz visits and coming back in via Continue.
So for those who just play through, you have no problems.
For those who come in for short play sessions and would often quit out, yes you may have ran against this bug.
So we will be putting out a patch to add an autosave for after Caz, but for now, please be aware and don't leave the game right after Cazaunoux visits.
Save manually or go to another New Orleans location if you have to leave the game right after.
I have also confirmed a few other places this can happen which I will list as a separate topic.
Very sorry for the pain this has caused some people.
Thank you for giving us the heads up!
And hope you enjoy the rest of the game!